Solving ME/CFS: what's newhttps://solvingmecfs.org/feed.xml2026-11-02T00:00:00ZSolving ME/CFSNew project: Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post-Acute Sequelae of SARS-CoV-2 (PD1-PASC I)tag:solvingmecfs.org,2026:p-trial-NCT073885502026-11-02T00:00:00Zlong COVID · National Institute of Neurological Disorders and Stroke (NINDS) USANew project: Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Findingtag:solvingmecfs.org,2026:p-trial-NCT072854732026-11-01T00:00:00ZME/CFS · University of Alabama at Birmingham USANew project: Fatigue in Long COVID Managed With Conservative Care: An International, Randomized Controlled Trial (FALCON Trial)tag:solvingmecfs.org,2026:p-trial-NCT076972612026-11T00:00:00Zlong COVID · McMaster University New project: SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD)tag:solvingmecfs.org,2026:p-trial-NCT075979022026-10-20T00:00:00Zlong COVID · Icahn School of Medicine at Mount Sinai USANew project: Multicentre study of the effectiveness of multimodal coaching interventions and the feasibility of point-of-care test device for improving the quality of life, functional capacity, and self-management in patients with myalgic encephalomyelitis/chronic fatigue syndrometag:solvingmecfs.org,2026:p-trial-ISRCTN160251682026-10-15T00:00:00ZME/CFS · Canada; FranceNew project: Prospective, Randomized, Double-blind, Placebo-controlled Phase 2a Trial of Low-dose Aripiprazole in Patients With Neuropsychiatric Impairment in Post-acute Infectious Syndrome (PAIS) Including Post-COVID-19 Condition (PCC)tag:solvingmecfs.org,2026:p-trial-NCT077142132026-10-01T00:00:00Zlong COVID · Christiana Franke GermanyNew project: Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Studytag:solvingmecfs.org,2026:p-trial-NCT078742172026-10T00:00:00Zboth · Oxford Brookes University UKNew project: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study to Evaluate the Safety, Pharmacokinetics, and Clinical Activity of VYD2311 for the Treatment of Adults With Long-COVID or Post-Vaccination Syndrome (FLINTLOCK)tag:solvingmecfs.org,2026:p-trial-NCT078993462026-10T00:00:00Zlong COVID · Invivyd, Inc. New project: The Central Role of mTOR in ME/CFS Pathogenesis.tag:solvingmecfs.org,2026:p-nih-RF1NS1463972026-09-25T00:00:00ZME/CFS · Simmaron Research Inc USANew project: Spatial Metabolomic Mapping of Long COVID Tissues Using MALDI Mass Spectrometry Imagingtag:solvingmecfs.org,2026:p-polybio-spatial-metabolomic-mapping-of-long-covid-tissues-using-maldi-mass-spectrometry-imaging2026-09-20T00:00:00Zlong COVID · New project: The Impact of Transcranial Direct Current Stimulation on Quality of Life, Brain Fog, and Fatigue in Patients With Long COVID: Study Protocol of the NEUROSTIM-LC Studytag:solvingmecfs.org,2026:p-trial-NCT077092342026-09-15T00:00:00Zlong COVID · University of Las Palmas de Gran Canaria New project: Neuro-PASC (Brain Fog and Fatigue) is Caused by a Dysbiotic Gut Microbiometag:solvingmecfs.org,2026:p-nih-R01NS1470192026-09-11T00:00:00Zlong COVID · University Of Texas Med Br Galveston USANew project: Observational Study With CICR-NAM as a Food for Special Medicinal Purposes in Post-COVID Syndrome (PCS)tag:solvingmecfs.org,2026:p-trial-NCT077985702026-09-06T00:00:00Zlong COVID · University Hospital Schleswig-Holstein New project: Dapagliflozin for Long COVID Syndrometag:solvingmecfs.org,2026:p-trial-NCT069072512026-09-01T00:00:00Zlong COVID · Ottawa Heart Institute Research Corporation CanadaNew project: Randomized Controlled Trial of Moderate Dose Hydrogen Water as a Treatment for ME/CFStag:solvingmecfs.org,2026:p-trial-NCT077531222026-08-15T00:00:00ZME/CFS · Fred Friedberg USANew project: Micro-choice-based Intervention for Multicausal Fatigue: Proof of Concept Studytag:solvingmecfs.org,2026:p-trial-NCT077260822026-08-13T00:00:00Zlong COVID · University Hospital, Basel, Switzerland SwitzerlandNew project: Identifying Biological Signatures for Long COVID Development in Salivatag:solvingmecfs.org,2026:p-nih-R01DE0357092026-08-01T00:00:00Zlong COVID · Univ Of North Carolina Chapel Hill USANew project: A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC)tag:solvingmecfs.org,2026:p-trial-NCT059314972026-08-01T00:00:00Zlong COVID · Massachusetts General Hospital USANew project: Early antiviral treatment to prevent viral persistence and inflammation as drivers of Long COVID: a proof-of-concept mechanistic trialtag:solvingmecfs.org,2026:p-nih-U01AI1920432026-07-21T00:00:00Zlong COVID · University Of California, San Francisco USANew project: Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - A Prospective, Randomized, Double-Blind, Sham-Controlled Studytag:solvingmecfs.org,2026:p-trial-NCT076210682026-07-19T00:00:00ZME/CFS · Assaf-Harofeh Medical Center IsraelNew project: Randomized Controlled Trial to Assess the Efficacy of a Supervised Computerized Active Program (SuperCAP) to Improve Cognition and Daily Functioning in People With Post-COVID-19 Conditiontag:solvingmecfs.org,2026:p-trial-NCT075307572026-07-15T00:00:00Zlong COVID · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia SpainNew project: A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVIDtag:solvingmecfs.org,2026:p-trial-NCT069740842026-07-15T00:00:00Zlong COVID · HealthBio, Inc. USANew project: Randomized adaptive assessment of post COVID syndrome treatments (RAPID): Evaluating the Efficacy of Bupropion for the Treatment of Post-COVID-19 Syndrome-associated Fatigue (ELAPSE)tag:solvingmecfs.org,2026:p-trial-2025-524443-12-002026-07-15T00:00:00Zlong COVID · Goethe University Frankfurt GermanyNew project: A Pilot Randomized Controlled Trial of Homeopathic Treatment for Long COVIDtag:solvingmecfs.org,2026:p-trial-NCT076942322026-07-15T00:00:00Zlong COVID · St. Mary's University, Twickenham UKNew project: Identification of molecular-neuropathological signatures in AD, FTLD and Long COVIDtag:solvingmecfs.org,2026:p-nih-K08AG0980352026-07-01T00:00:00Zlong COVID · University Of California Los Angeles USANew project: DISCOVER-ME: Biological evidence and mechanism-based disease classification for the improved diagnosis, prognosis and treatment of ME/CFS (DISCOVER-ME)tag:solvingmecfs.org,2026:p-cordis-1012877662026-07-01T00:00:00ZME/CFS · Medizinische Universitaet Wien AustriaNew project: Brain Training for Chronic, Post-viral, Brain Fog: Study Atag:solvingmecfs.org,2026:p-trial-NCT075231132026-06-23T00:00:00Zboth · University of Alabama at Birmingham USANew project: The Role of Photobiomodulation in Patients With Chronic Fatigue Syndrometag:solvingmecfs.org,2026:p-trial-NCT075465392026-06-15T00:00:00ZME/CFS · University of Lahore PakistanNew project: sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRITtag:solvingmecfs.org,2026:p-trial-NCT073594822026-06-04T00:00:00Zlong COVID · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) NetherlandsNew project: Urinary Extracellular Vesicle Profiling to Identify Borrelia-Associated Neuroimmune Subtypes in Long COVIDtag:solvingmecfs.org,2026:p-polybio-urinary-extracellular-vesicle-profiling-to-identify-borrelia-associated-neuroimmune-subtypes-in-long-covid2026-06-03T00:00:00Zlong COVID · New project: Infection-Triggered Neurodegeneration in Long COVID: Retinal Biomarkers and Organoid Models for Mechanism and Therapytag:solvingmecfs.org,2026:p-polybio-infection-triggered-neurodegeneration-in-long-covid-retinal-biomarkers-and-organoid-models-for-mechanism-and-therapy2026-06-03T00:00:00Zlong COVID · New project: REenergizeME: Oxygen Therapy (OT) as a Novel Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)tag:solvingmecfs.org,2026:p-trial-NCT073174012026-06-01T00:00:00ZME/CFS · University of Aarhus DenmarkNew project: Phase II, Proof of Concept, Open-Label, Randomized-Controlled Trial Evaluating the Efficacy and Safety of PARAGON Novel Metabolic Regulator Formula (PNMR) in the Management of Long COVIDtag:solvingmecfs.org,2026:p-trial-NCT076278152026-05-20T00:00:00Zlong COVID · ParagonClinicals Inc. CanadaNew project: A Randomized Controlled Trial for Cervicothoracic Sympathetic Chain Block Against Placebo Saline Injection Evaluation for Post COVID Condition: the CeASE RCTtag:solvingmecfs.org,2026:p-trial-NCT074686042026-05-19T00:00:00Zlong COVID · University Health Network, Toronto CanadaNew project: Stratification of ME/CFS by mycotoxin exposuretag:solvingmecfs.org,2026:p-nih-R01NS1488452026-05-08T00:00:00ZME/CFS · Nova Southeastern University USATrial result: Insights from a double-blind, randomized, direct-to-participant intervention trial for Long COVIDtag:solvingmecfs.org,2026:t-10.64898/2026.08.19.263608322026-01-01T00:00:00Zinjectable repurposed drug (decentralised trial) · long COVID · not-assessableTrial result: Nirmatrelvir-ritonavir targeting viral persistence in post-COVID-19 condition (long COVID) in the USA (RECOVER-VITAL): a randomised, double-blind, placebo-controlled, phase 2 trial.tag:solvingmecfs.org,2026:t-426739842026-01-01T00:00:00Znirmatrelvir/ritonavir · long COVID · nullTrial result: The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.tag:solvingmecfs.org,2026:t-419115532026-01-01T00:00:00Zfluvoxamine + metformin · both · mixedTrial result: Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.tag:solvingmecfs.org,2026:t-417711352026-01-01T00:00:00Zmetformin / ursodeoxycholic acid · long COVID · nullTrial result: Evaluation of Interventions for Cognitive Symptoms in Long COVID: A Randomized Clinical Trial.tag:solvingmecfs.org,2026:t-412125442026-01-01T00:00:00Zcognitive rehabilitation + transcranial stimulation/neurofeedback · long COVID · nullTrial result: [Compound Ciwujia Granules for chronic fatigue syndrome with syndrome of deficiency of both heart and spleen: a multicenter, randomized, double-blind, double-dummy, positive drug-controlled trial].tag:solvingmecfs.org,2026:t-425433772026-01-01T00:00:00Zherbal/TCM · ME/CFS · positiveTrial result: Temelimab versus placebo in patients with post-COVID condition.tag:solvingmecfs.org,2026:t-424091852026-01-01T00:00:00Ztemelimab · long COVID · nullTrial result: Evaluation of an integrated multidisciplinary care model for myalgic encephalomyelitis/chronic fatigue syndrome: A prospective, open-label, non-randomized controlled intervention study.tag:solvingmecfs.org,2026:t-427726582026-01-01T00:00:00Zintegrated multidisciplinary care · ME/CFS · nullTrial result: Low Dose Naltrexone for Post-COVID Fatigue Syndrome: A Randomized Controlled Trialtag:solvingmecfs.org,2026:t-10.64898/2026.10.22.263635822026-01-01T00:00:00Zlow-dose naltrexone · both · nullTrial result: Tele-rehabilitation for individuals with long COVID: a randomised clinical trial.tag:solvingmecfs.org,2026:t-425491262026-01-01T00:00:00Zvirtual rehabilitation (exercise) · long COVID · mixedTrial result: Symptom-based rehabilitation in people with post-COVID-19 condition (RELOAD study): a randomised controlled trial.tag:solvingmecfs.org,2026:t-421614182026-01-01T00:00:00Zexercise/rehabilitation · long COVID · positiveTrial result: Testing the Feasibility of a Self-Help Intervention That Includes Lymphatic Drainage to Reduce Fatigue-Related Symptoms Among Patients with Long COVID in General Practice: Experiences from Our Randomized Controlled Trial (RCT).tag:solvingmecfs.org,2026:t-414421052026-01-01T00:00:00Zself-help lymphatic drainage · long COVID · feasibility-onlyTrial result: Treatment effects of multimodal inpatient psychotherapy for post-COVID patients: First results from a non-randomized, controlled study.tag:solvingmecfs.org,2026:t-417954022026-01-01T00:00:00Zmultimodal inpatient psychotherapy · long COVID · mixedTrial result: Effectiveness of an Exercise-Based Telerehabilitation on Cardiorespiratory Fitness, Gait Speed, and Symptoms in Individuals with Long COVID: A Randomized Controlled Trialtag:solvingmecfs.org,2026:t-10.21203/rs.3.rs-10999234/v12026-01-01T00:00:00ZKNEESUP smart knee assistive device + KNEESUP care APP; Healthy consulation · long COVID · positiveTrial result: Impact of Pulmonary Rehabilitation on Physical, Mental Health and Quality of Life in Children with Post-COVID-19 Condition: A 12-Month Quasi-Experimental Study.tag:solvingmecfs.org,2026:t-415984732026-01-01T00:00:00Zmultidisciplinary rehabilitation · long COVID · positiveTrial result: Effect of Percutaneous Auricular Nerve Stimulation on Fatigue in Adults with Post-COVID Fatigue (PAuSing-pCF): Results of a Randomised, Sham-Controlled Trialtag:solvingmecfs.org,2026:t-10.3310/nihropenres.14236.12026-01-01T00:00:00Zauricular vagus nerve stimulation · long COVID · nullTrial result: Digital rehabilitation using immersive Virtual Reality for Post-COVID fatigue: a double-blind randomized controlled trial.tag:solvingmecfs.org,2026:t-428094802026-01-01T00:00:00Zimmersive VR + exercise/rehabilitation · long COVID · nullTrial result: Herbal medicine (Kyungok-go) for fatigue in Long COVID patients: A prospective multicenter pilot study.tag:solvingmecfs.org,2026:t-420880122026-01-01T00:00:00ZKyungok-go (Korean herbal) · long COVID · positiveTrial result: Cognitive Rehabilitation and Functional Outcomes in Long COVID-Related Cognitive Impairment: A Randomized Clinical Trial.tag:solvingmecfs.org,2026:t-423843842026-01-01T00:00:00Zcognitive rehabilitation · long COVID · positiveTrial result: An open-label feasibility study of remdesivir in long COVID: results from the ERASE LC trial.tag:solvingmecfs.org,2026:t-428910152026-01-01T00:00:00Zremdesivir · long COVID · feasibility-onlyTrial result: An open-label, clinical feasibility study of the efficacy of Remdesivir for Long-COVID.tag:solvingmecfs.org,2026:t-420632022026-01-01T00:00:00Zremdesivir · long COVID · feasibility-onlyTrial result: Preliminary evaluation of a cognitive rehabilitation intervention for post-COVID-19 cognitive impairment: A pilot randomized controlled trial.tag:solvingmecfs.org,2026:t-409916472026-01-01T00:00:00Zcognitive rehabilitation · long COVID · mixedTrial result: Resting-State Functional Connectivity and Cognitive Performance in Long COVID: A Randomized Controlled Trialtag:solvingmecfs.org,2026:t-10.64898/2026.10.05.263645312026-01-01T00:00:00Zcognitive rehabilitation · long COVID · mixedTrial result: Creatine supplementation on fatigue related to post-COVID-19 condition-fatigue study: a randomized controlled trial.tag:solvingmecfs.org,2026:t-419589092026-01-01T00:00:00Zcreatine · long COVID · positiveTrial result: Transcranial direct current stimulation-augmented cognitive training for post-COVID-19 cognition: A phase IIb randomized controlled trialtag:solvingmecfs.org,2026:t-10.64898/2026.05.11.263529062026-01-01T00:00:00Ztranscranial stimulation/neurofeedback + cognitive rehabilitation · long COVID · mixedTrial result: Evaluation of a multidisciplinary neurological rehabilitation program for the post-COVID-19 condition.tag:solvingmecfs.org,2026:t-417237562026-01-01T00:00:00Zmultidisciplinary neurological rehabilitation · long COVID · mixedTrial result: Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial.tag:solvingmecfs.org,2026:t-417531542026-01-01T00:00:00Zpolyphenol/omega-3/anti-inflammatory supplement · both · positiveTrial result: Transcutaneous Auricular Vagal Nerve Stimulation Against Fatigue Syndrome in Patients with Long COVID: Results of the Randomized, Placebo-Controlled Clinical Pilot Trial COVIVA.tag:solvingmecfs.org,2026:t-419260332026-01-01T00:00:00Ztranscutaneous auricular VNS · long COVID · nullTrial result: Effect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.tag:solvingmecfs.org,2026:t-422803502026-01-01T00:00:00ZL-citrulline · long COVID · positiveTrial result: Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial.tag:solvingmecfs.org,2026:t-423181672026-01-01T00:00:00Zimmunoadsorption/apheresis · long COVID · nullTrial result: Effects of inspiratory muscle training on exercise capacity, muscle oxygenation and strength, physical activity, and dyspnea in patients with post-COVID-19 syndrome and pulmonary involvement: a randomized controlled triple-blinded study.tag:solvingmecfs.org,2026:t-419060712026-01-01T00:00:00Zbreathing/respiratory training · long COVID · positiveTrial result: Efficacy of major ozone autohemotherapy in patients with post-COVID syndrome.tag:solvingmecfs.org,2026:t-417675302026-01-01T00:00:00Zozone autohaemotherapy · long COVID · positiveTrial result: A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVIDtag:solvingmecfs.org,2026:t-10.64898/2026.03.07.263478572026-01-01T00:00:00ZSARS-CoV-2 monoclonal antibody · long COVID · nullTrial result: Photobiomodulation for cognitive dysfunction (Brain Fog) in post-COVID-19 condition: a randomized double-blind sham-controlled pilot trial.tag:solvingmecfs.org,2026:t-417689812026-01-01T00:00:00Zphotobiomodulation · long COVID · mixedTrial result: REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial.tag:solvingmecfs.org,2026:t-416259632026-01-01T00:00:00Zcell therapy (MSC/cord blood) · long COVID · positiveTrial result: [Neurocognitive functioning after cognitive treatment in post-COVID].tag:solvingmecfs.org,2026:t-425223412026-01-01T00:00:00Zgroup cognitive treatment · long COVID · mixedTrial result: Feasibility and outcomes of crossflow membrane plasmapheresis for long COVID in Suriname: a randomized double-blind placebo-controlled pilot trialtag:solvingmecfs.org,2026:t-10.12688/f1000research.186744.12026-01-01T00:00:00Ztherapeutic plasma exchange · long COVID · nullTrial result: The Use of a Handheld Non-Invasive Vagal Nerve Stimulation (nVNS) Device for the Treatment of Long COVID: A Pilot Randomized Controlled Trial.tag:solvingmecfs.org,2026:t-425010052026-01-01T00:00:00Znon-invasive vagus nerve stimulation (gammaCore) · long COVID · nullTrial result: Long COVID brain fog treatment: An early-phase randomized controlled trial of constraint-induced cognitive therapy signals go.tag:solvingmecfs.org,2026:t-403102092026-01-01T00:00:00Zexercise/rehabilitation · long COVID · positiveTrial result: Potential Adjunctive Effects of Quercetin-Curcumin Co-Supplementation in Adults with Mild-to-Moderate Long COVID: Results from a Pragmatic Exploratory Real-World Clinical Study.tag:solvingmecfs.org,2026:t-426536992026-01-01T00:00:00Zpolyphenol/omega-3/anti-inflammatory supplement · long COVID · positiveTrial result: A Short-Term Pacing Intervention in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study in Portugal.tag:solvingmecfs.org,2026:t-417527302026-01-01T00:00:00Zpacing education · ME/CFS · feasibility-onlyTrial result: Metformin for fatigue and cognitive dysfunction associated with postCOVID-19 condition and other suspected mitochondrial dysfunction: a case seriestag:solvingmecfs.org,2026:t-10.21203/rs.3.rs-9517130/v12026-01-01T00:00:00Zmetformin · long COVID · positiveTrial result: Effects of Tai Chi on fatigue and resting-state brain activity in chronic fatigue syndrome: a randomized controlled fMRI study.tag:solvingmecfs.org,2026:t-427802162026-01-01T00:00:00ZTai Chi · ME/CFS · positiveTrial result: Multi-Strain Probiotic Improves Tryptophan Metabolism and Symptoms in Chronic Fatigue Syndrome Patients with Co-Occurring Irritable Bowel Syndrome: An Open-Label Pilot Study.tag:solvingmecfs.org,2026:t-415152902026-01-01T00:00:00Zmulti-strain probiotic · ME/CFS · positiveTrial result: Effect of Prolong Life With Nine Turn Method on chronic fatigue syndrome clinical symptoms and roles of gut microbiota: A exploratory randomized controlled trial.tag:solvingmecfs.org,2026:t-418069582026-01-01T00:00:00Zabdominal massage (Nine Turn method) · ME/CFS · positiveTrial result: Tuina therapy for patients with chronic fatigue syndrome: a randomized controlled trial.tag:solvingmecfs.org,2026:t-415079062026-01-01T00:00:00ZTuina massage · ME/CFS · positiveTrial result: A preliminary proof-of-concept trial on the effects of ketamine on fatigue: a randomized crossover trial.tag:solvingmecfs.org,2026:t-415694032026-01-01T00:00:00Zketamine · ME/CFS · mixedTrial result: Efficacy and Safety of Enzyme-Derived Deer Velvet Extract Supplementation on Adults with Chronic Fatigue: a Randomized, Placebo-Controlled, Double-Blind Trial.tag:solvingmecfs.org,2026:t-424874022026-01-01T00:00:00Zdeer velvet extract · ME/CFS · positiveTrial result: Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.tag:solvingmecfs.org,2026:t-416833432026-01-01T00:00:00Zvitamin D · both · positiveTrial result: Effectiveness of adapted physical activity and therapeutic exercise programme in improving chronic fatigue syndrome in long COVID, delivered via hospital-based rehabilitation versus telerehabilitation.tag:solvingmecfs.org,2026:t-423107052026-01-01T00:00:00Zadapted physical activity/exercise · long COVID · positive